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SETAC Europe 26th Nantes 22nd – 26th May 2016

Tom Miller, current PhD student with Dr. Leon Barron, gave two excellent talks on his recent work assessing pharmaceutical uptake in Gammarus pulex Bioconcentration and biotransformation of selected pharmaceuticals in the freshwater amphipod, Gammarus pulex and the use of POCIS to monitor water contaminants (In silico prediction of sampling rates for polar organic chemical integrative samplers (POCIS)).

Nic Bury also chaired a session on Metal Mixtures (Interpreting Biological Effects of Metals and Their Mixtures: Chairs Eric J. Van Genderen, Nicolas Bury).

Methods for culturing FIGCS published in Nature Protocols

New CEFIC-LRI Grant (€ 500,000) with Prof. Kristin Schirmer (EAWAG) (Lead PI), Prof Helmut Segner (University of Bern), Dr Jon Arnot (Arnot Research and Consulting Inc) and Dr Michelle Embury (ILSI) entitled A tiered testing strategy for rapid estimation of biaccumualtion by a combined modelling – in vitro test approach.

It is acknowledged that biotransformation is an uncertainty when estimating the bioaccumulation of organic chemicals. The aim of the current project is to develop in vitro methods, that include models of the gill, gut and liver as well as cell lines, as a rapid assessment for uptake and biotransformation pathways of chemicals.

For more details see http://cefic-lri.org/projects/eco34-a-tiered-testing-strategy-for-rapid-estimation-of-bioaccumulation-by-a-combined-modelling-in-vitro-testing-approach/

FiGCS Awarded £10,000 BBSRC Sparking Impact Award

The Sparking Impact competition invited researchers at King’s to submit a project proposal that develops the impact of a current BBSRC project with the aim to develop project management skills, particularly in young researchers. This prize, awarded to Lucy Stott and Nic Bury, was for their project that aimed to promote the use of alternative methods in ecotoxicology testing, using a primary gill cell culture system.

Read more on the Kings College London website

Study investigates extraordinary trout with tolerance to heavily polluted water

New research from the University of Exeter and King’s College London has shown how a population of brown trout can survive in the contaminated waters of the River Hayle in Cornwall where metal concentrations are so high they would be lethal to fish from unpolluted sites.

The team believe this is due to changes in the expression of their genes. The research was funded by NERC and the Salmon and Trout Association.

Read the full article on the University of Exeter Website

The trout that like heavy metal

Contaminated during the surrounding area’s history of mining, the River Hayle in Cornwall contains metals including copper, zinc, nickel and cadmium at levels that can kill brown trout, a particularly sensitive species. It comes as a surprise, then, that brown trout in this river show no obvious signs of toxicity and are apparently flourishing. We set out to investigate how these fish might be able to tolerate such extreme exposure to toxic metals.

Read the full article on TheConversation.com