The overall objective of our research is to reduce the uncertainty related to the estimation of bioaccumulation of organic chemicals in fish in ecological risk assessment (ERA). Based on a combination of different in vitro approaches to estimate chemical uptake and biotransformation with toxicokinetic (TK) and quantitative structure activity relationship (QSAR) models, we aim to develop a tiered approach, integrating modelling with testing strategies to aid in the rapid assessment of bioaccumulation potential (Figure 1). The tiered testing strategy can provide information and guidance for (1) bioaccumulation (hazard) assessment; (2) refining exposure estimation to support risk assessment; (3) TK models to aid in the interpretation of toxicity testing data and to guide experimental testing; and (4) knowledge as input into adverse outcome pathways (AOPs) to strengthen quantitative links between molecular or cellular events and apical effects.
Principal Investigator Prof. Kristin Schirmer with collaboration from:
- Prof Christer Hogstrand, Professor of Molecular Ecotoxicology, King’s College London, London, UK
- Dr Nic Bury, University of Suffolk, UK
- Prof Helmut Segner, Professor, University of Bern (UoBern), Bern, Switzerland
- Dr Jon Arnot, President, ARC Arnot Research and Consulting Inc., Toronto, ON, Canada
- Dr Michelle Embry, Associate Director, Environmental Science, ILSI Health and Environmental Sciences Institute, Washington, USA